TAGMe DNA Methylation Detection rau Pan-cancer
Khoom nta
Minimally invasive kev kho mob:Extract tsawg kawg yog 3mL Peripheral venous ntshav los yog lwm yam kev soj ntsuam kuaj cov qauv
Qhov tseeb:Txais cov ntaub ntawv loj thiab AI algorithm, kuaj qhov tshwj xeeb≥95%
Versatility:Ib qho kev kuaj pom tuaj yeem npog 25 qhov mob qog nqaij hlav loj.
Thaum ntxov:Kev cuam tshuam los ntawm kev kuaj mob qog noj ntshav thaum ntxov, thoob plaws tag nrho cov txheej txheem ntawm kev kuaj mob qog noj ntshav thiab kev kho mob.
Yooj yim:Txais cov qauv kub rau kev tshawb pom methylation - pyrophosphate sequencing thev naus laus zis, tuaj yeem ua tiav qhov kev sim hauv 4 teev.
Txoj cai:Nrog 54 thoob ntiaj teb thiab hauv tsev patents, cov txiaj ntsig kev tshawb fawb cuam tshuam tau luam tawm hauv Kev Tshawb Fawb Cancer, Genome Research thiab lwm cov ntawv xov xwm nto moo thoob ntiaj teb.
Detection Principple
Kev kuaj mob qog noj ntshav tag nrho yog plasma ctDNA methylation kuaj cov khoom tsim los ntawm TAGMe, uas yuav tsum muaj tsawg kawg 3ml ntawm cov ntshav tag nrho kom ua tau zoo thiab txiav txim siab txog qhov xwm txheej methylation ntawm ctDNA cov ntsiab lus tshwj xeeb, kom ua tiav qhov kev tshuaj ntsuam ntxov thiab kev saib xyuas raug. ntawm qog.
Kev ua tau zoo
Hauv kev txheeb xyuas ntau dua 3000 qhov kev kuaj mob, qib methylation ntawm TAGMe hauv cov ntaub so ntswg tau nce siab dua li cov ntaub so ntswg.Yog li ntawd, TAGMe tuaj yeem siv los ua tus cim kab mob qog noj ntshav rau kev kuaj pom ntau yam qog noj ntshav.
Cov noob caj noob ces yog hypermethylated hauv ntsws cancer thiab hypermethylated HIST1H4F tuaj yeem ua tus pan-cancer biomarker
--- Kev Tshawb Fawb Cancer, IF: 12.7
Raws li tus cim kab mob pancreatic, TAGMe muaj qhov tshwj xeeb thiab rhiab heev hauv kev kuaj xyuas cov qauv kuaj xyuas, uas muaj qhov tseem ceeb siv tus nqi rau kev kuaj mob ntawm cov qog.
TAGMe's rhiab nyob rau hauv cov qauv qog sib txawv thaum qhov tshwj xeeb yog ntau dua 95%,
Daim ntawv thov scenarios
Tsev neeg keeb kwm ntawm mob qog noj ntshav:Cov neeg mob qog noj ntshav tam sim ntawd lossis cov txheeb ze.
Kab mob kis kab mob thiab kab mob ntev:Xws li HPV, HBV thiab lwm yam kab mob kis, plab hnyuv polyps, mob atrophic gastritis thiab daim siab cirrhosis, thiab lwm yam.
Tshaj tawm rau ib puag ncig carcinogenic rau lub sijhawm ntev:Raug rau ib puag ncig hluav taws xob lossis tshuaj lom neeg rau lub sijhawm ntev.
Suspected qog mob:xws li qhov chaw mos los ntshav, hematochezia, tso zis, lub ntsws nodules, tsis tau piav qhia tsis tshua muaj kub taub hau lossis emaciation, thiab lwm yam.
Cov cwj pwm tsis zoo nyob mus ntev: Kev haus luam yeeb ntev lossis kev haus luam yeeb ntev, haus ntau dhau, noj kub lossis haus dej kub, noj ntsev ntau, pickled, pwm, haus luam yeeb thiab kib, thiab lwm yam.
Ua tib zoo saib xyuas tus kheej noj qab haus huv:tshwj xeeb tshaj yog rau cov neeg muaj hnub nyoog tshaj 40 xyoo
